Articles

Biodegradable Zinc-Magnesium Alloy Scaffolds with Controlled Porosity for Bone Tissue Engineering

Felix Weber , Xiaoming Li , Ayesha Khan
Published: 2026-04-20 DOI: doi.org/10.55001/jams.v1i1.40 https://doi.org/10.55001/jams.v1i1.40 Vol. 1 No. 1 (2026)
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Abstract

This work reports the design, fabrication, and in vitro evaluation of biodegradable Zn-3Mg alloy scaffolds with graded porosity produced by selective laser melting (SLM). Three scaffold architectures with porosities of 45%, 60%, and 75% were designed using triply periodic minimal surface (TPMS) gyroid topology. Mechanical testing revealed that the 60% porosity scaffold achieves a compressive strength of 48 MPa and elastic modulus of 3.2 GPa, closely matching the properties of cancellous bone. In vitro degradation studies in simulated body fluid (SBF) demonstrated a controlled corrosion rate of 0.18 mm/year, with the formation of biocompatible hydroxyapatite surface layers. Cell culture experiments with MC3T3-E1 osteoblasts confirmed excellent cytocompatibility with >92% cell viability after 7 days.

Author Biographies

  • Felix Weber Institute of Biomaterials, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany
    Felix Weber is a research fellow at Institute of Biomaterials, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany. Their research focuses on machine learning, with over 70 publications in peer-reviewed journals.
  • Xiaoming Li School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
    Xiaoming Li is a research fellow at School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. Their research focuses on machine learning, with over 50 publications in peer-reviewed journals.
  • Ayesha Khan Department of Materials Engineering, Monash University, Clayton VIC 3800, Australia
    Ayesha Khan is a research fellow at Department of Materials Engineering, Monash University, Clayton VIC 3800, Australia. Their research focuses on social sciences, with over 67 publications in peer-reviewed journals.
JAMS Vol. 1, No. 1, 2026
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Authors

  • Felix Weber Institute of Biomaterials, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany
  • Xiaoming Li School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
  • Ayesha Khan Department of Materials Engineering, Monash University, Clayton VIC 3800, Australia

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